유기산성약물이 푸로세미드의 흡수, 배설 및 이뇨효과에 미치는 영향

• 영문명: The Effects of Organic Acidic Drugs on the Absorption, Excretion and Diuretic Action of Furosemide
• 발행기관: 대한약학회
• 저자명: 염윤희(Yoon Hee Yeom) 용재익(Jae Ick Yong)
• 간행물 정보: 『약학회지』제31권 제5호 (1987년), 273~279쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1987.10.30

영문 초록

The effects of organic acidic drugs on the absorption, excretion and diuretic action of furosemide were studied. Cefalexin, p-aminohippuric acid (PAH), ibuprofen and p-aminosalicylic acid (PAS) were selected as organic acidic drugs. The in situ absorption rate and absorption rate constant of furosemide (30mcM) were significantly (p<0.05) decreased by 3OmcM of cefalexin, PAH, ibuprofen and PAS in rat small intestine. The plasma concentration of furosemide was significantly (p<0.01) increased by cefalexin, PAH and ibuprofen in rabbits. But the urinary excretion rate, renal clearance and diuretic action of furosemide were significantly (p<0.05) decreased by cefalexin, PAH, ibuprofen and PAS in rabbits.