신경세포의 Myelination에 있어서 Myelin Basic Protein의 Methyl화 현상에 관한 연구

• 영문명: Study on the Effects of Methylation of Myelin Basic Protein in Myelination of Nerve Cells
• 발행기관: 대한약학회
• 저자명: 이향우(Hyang Woo Lee) 전재광(Jae Kwang Jeon)
• 간행물 정보: 『약학회지』제31권 제5호 (1987년), 266~272쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1987.10.30

영문 초록

It is reasonably well known that there is a relationship between myelin formation and methylation of myelin basic protein in nerve cells. One of the suggestions is that arginine methylation of myelin basic protein could be of aid in the conjugation of myelin protein with the nonpolar lipid to form myelin. Abnormality in methylation of myelin basic protein might induce the neurological diseases in experimental animals as well as in human being. In the biological system, the methylation reaction is catalyzed by protein methaylase I using S-adenosyl-L-methionine as methyl donor. In this study, we examined the changes of S-adenosyl-L-methionine concentration and protein methylase I activity in developing rat brain tissues. The results are summerized as followings: (1) In brain tissues of fetus rat, the concentration of S-adenosyl-L-methionine was gradually decreased until to birth. However, the concentration in brain tissues of infant rat was suddenly increased at 7th day (just before myelination occur) birth. (2) Protein methylase I activity was decreased until to birth in brain of fetus rat and increased temporally just after birth. However, the enzyme activity showed no changes around 7th day after birth.