Vitamin B6와 Pyrazinamide의 약물상호작용(II) Pyrazinoic acid 대사에 미치는 pyridoxal의 영향

• 영문명: Drug Interaction of Vitamin B6 and Pyrazinamide(II) Effect of Pyridoxal on the Pyrazinoic Acid Oxidizing Enzyme Activity
• 발행기관: 대한약학회
• 저자명: 허근(Keun Huh) 이상일(Sang Il Lee) 박종민(Jong Min Park) 김석환(Suk Hwan Kim)
• 간행물 정보: 『약학회지』제31권 제4호 (1987년), 197~203쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1987.08.30

영문 초록

When pyrazinamide is used in the treatment of tuberculosis, the measurement of pyrazinoic acid which is an intermediate metabolite of pyrazinamide in body is required in order to prevent its associated side-effects, especially that of hyperuricemia. Effects of vitamin B6 on pyrazinoic acid metabolism were studied in this experiment. The activity of hepatic pyrazinoic acid oxidizing enzyme in the presence of pyridoxal was powerfully inhibited, and the pattern was competitive inhibition type. Whereas, its enzyme activity was significantly increased by the treatment of pyridoxal, and the characteristics of the increase may include induction of enzyme proteins. As mice received pyrazinoic acid(300mg/kg) after pyridoxal-pretreatment(40mg/kg) once daily for 4 days, the blood level of pyrazinoic acid and uric acid was decreased significantly.