필치가 혈중 알코올농도와 간세포내 알코올대사 효소 활성에 미치는 영향

• 영문명: Effect of Feelch on Blood Alcohol Concentration in Human and Hepatic Alcohol Metabolizing Enzyme Activity in Alcohol-Fed Rats
• 발행기관: 대한약학회
• 저자명: 이오미(O Mi Lee) 예충민(Choong Min Ye) 최병철(Byung Chul Choi) 이지윤(Ji Yun Lee) 강혜정(Hye Jeong Kang) 최윤경(Yun Kyung Choi) 김창종(Chang Jong Kim) 심상수(Sang Soo Sim)
• 간행물 정보: 『약학회지』제49권 제4호 (2005년), 340~346쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2005.08.31

영문 초록

To investigate the effect of Feelch on alcohol metabolism, we measured both blood alcohol concentration in human and hepatic alcohol metabolizing enzyme activity in rats. The blood alcohol concentration in Feelch-ingested group was significantly lower than that in water-ingested group at 0, 40, and 80 minute after alcohol intake. The blood alcohol concentration between male and female taken 300 ㎖ of 21% alcohol showed the significant differences; the peak value of blood alcohol concentration in male and female were 0.0837±0.014% and 0.108±0.018%, respectively, In alcohol-fed rats, aldehyde dehydrogenase (ALDH) activity was significantly increased, whereas alcohol dehydrogenase (ADH) activity was not changed. In both Feelch-fed group and Feelch plus alcohol-fed group, ADH and ALDH activity were significantly increased as compared with each control group. Feelch decreased phospholipase A₂ activity and lipid peroxidation in hepatic tissue and activities of serum aminotransferases as compared with control. These results suggest that Feelch may have a hepato-protective effects and this is likely due to lower blood alcohol concentration via the increment of hepatic ADH and ALDH activity.

키워드

Feelch alcohol ADH ALDH liver