갯방풍 지상부 정유 및 그 주성분의 항생제 감수성 및 내성 Streptococcus pneumoniae 균주에 대한 억제효과

• 영문명: In Vitro Inhibitory Activities of Essential Oils from the Aerial Parts of Glehnia littoralis and its Main Components Against Antibiotic-Susceptible and Resistant Strains of Streptococcus pneumoniae
• 발행기관: 대한약학회
• 저자명: 신승원(Seungwon Shin)
• 간행물 정보: 『약학회지』제49권 제4호 (2005년), 312~316쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2005.08.31

영문 초록

To develope a new natural antibiotics from Koran plant resources for dealing with the current situation regarding the rapid increase in antibiotic-resistant pathogen, the in vitro inhibitory activities of essential oils from the young leaves of Glehnia littoralis (Umbelliferae) as well as its main constituents were evaluated against susceptible and resistant species of Streptococcus pneumoniae. The essential oil fraction of G. littoralis and its main components, α- and β-pinene, exhibited significant inhibitory activities against the antibiotic-susceptible and resistant strains of S. pneumoniae, with MICs (minimum inhibiting concentrations) ranging from 4.0 mg/㎖ to 16 mg/㎖. No remarkable differences were shown between the susceptible and resistant strains. Moreover, the disk diffusion test disclosed that these inhibitory activities were dose-dependent. Furthermore, data from the checkerboard titer test with FICls (fractional inhibiting concentration indices) from 0.15 to 0.28 indicated synergisms between norfloxacin and α- or β-pinene in activity against S.pneumoniae KCCM49629 and S. pneumoniae CCARM4059.

키워드

essential oil Glehnia littoralis Streptococcus pneumoniae antibiotic-resistance norfloxacin combination α-pinene β-pinene