Ob/ob Mouse 에서 비탐-에스의 알코올성 지방산 개선 활성

• 영문명: Bitam-S Improves the Non-alcoholic Fatty Liver Disease in C57BL/6J ob/ob Mice
• 발행기관: 대한약학회
• 저자명: 한은정(Eun Jung Han) 김애경(Ae Kyung Kim) 정성현(Sung Hyun Chung)
• 간행물 정보: 『약학회지』제49권 제4호 (2005년), 306~311쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2005.08.31

영문 초록

Semisulospira libertine (SL) has been used as a folk medicine for quenching a thirst, hepatic fever and inflammation in oriental countries. Although SL has been anecdotally ascertained to ameliorate the hepatic diseases, there are no sufficient experimental evidences. The purpose of this study was to examine the effect of Bitam-S, in which SL is a main component, on non-alcoholic fatty liver disease manifested in C57BL/6J ob/ob mice. At 6 week old, the ob/ob mice were ran- domly divided into four groups; control and three treatment groups. The control mice was to receive a regular diet, and the treatment groups were fed a regular diet with either 250 mg/kg ,500 mg/kg of Bitam-S (BS250 and BS500) or 300 mg/kg of metformin (MT300) for a 8-week period. Bitam-S exerted beneficial effects on lipid homeostasis in ob/ob mice that are not necessarily due to its ability to decrease food intake but its specific effects on hepatic lipogenesis related genes (SREBP1a, FAS and SCD-1). The combined effects of Bitam-S to reduce body weight and lipogenic gene expressions, and reduce the deposition of triglyceride in the liver are indicative of a marked improvement in obesity-related non-alcoholic fatty liver disease. Taken together, Bitam-S has potential as a treatment agent for non-alcoholic fatty liver disease and deserves clinical trial in the near future.

키워드

Bitam-S non-alcoholic fatty liver disease lipogenesis related genes