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• 영문명: Preparation and Evaluation of Paclitaxel Nano-particle Delivery System for Parenteral Formulations
• 발행기관: 대한약학회
• 저자명: 전일순(Il Soon Jeon) 김정수(Jeong Soo Kim) 이계원(Gye Won Lee) 지웅길(Ung Kil Jee)
• 간행물 정보: 『약학회지』제49권 제4호 (2005년), 268~274쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2005.08.31

영문 초록

Paclitaxel is an effective antineoplastic agent against ovarian, colon and breast tumors. But there have been many difficulties to formulate this drug due to the extremely low aqueous solubility. Paclitaxel is currently formulated in a vehicle composed of Cremophor EL and absolute ethanol mixture which is 5~20 fold diluted in normal saline or 5% dextrose solution before I.V. injection. However, this formulation has many problems such as allergic reactions and drug precipitation on aqueous dilution. To overcome these problems, we prepared the micelle and microemulsion systems for parenteral administration of paclitaxel by using glycofurol, Solutol？？ HS 15 and oleic acid. Phase diagram, pH-rate stability, particle size distributions and pharmacokinetics of the systems were studied. Micelles and microemulsions formulated as nano-particle delivery system were physically and chemically stable. Therefore, these formulations might be the promising alternative candidate for the parenteral delivery of paclitaxel.

키워드

paclitaxel microemulsion micelle nano-particle glycofurol Solutol？？ HS 15 oleic acid