PGE1 요도좌제의 제조 및 평가

• 영문명: Preparation and Evaluation of PGE1 Urethral Suppositories
• 발행기관: 대한약학회
• 저자명: 박소민(Somin Park) 최명신(Myeongsin Choi) 한규원(Kyuwon Han) 김길수(Kil Soo Kim)
• 간행물 정보: 『약학회지』제49권 제4호 (2005년), 260~267쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2005.08.31

영문 초록

PGE₁ is an endogenous substance of potent vasodialator as well as inhibitor of platelet aggregation. It has been used therapeutically in peripheral arterial occlusive disease and impotence. Intracavernous injection of PGE₁ for erectile dysfunction has been established for several years as a treatment option for erectile dysfunction of diverse etiologies, but this mode of administration is limited by penile discomfort, pain at the injection site, inconvenience and noncompliance. As the matter of worse, the β-hydroxy moiety of PGE₁ is extremely susceptible to dehydration in solution to give inactive PGA₁and PGB₁. For the improvement of stability, rapid absorption at action site and the convenience of application, PGE₁ was formulated as urethral suppositories of three types of formulations, such as PEG, witepsol, and the mixture of PEG and witepsol. The stability test of PGE₁ and the release test in urinary suppositories were performed. Futhermore, the effect of enhancers and vehicle composition on the penetration of PGE₁ through excised rat skin was evaluated by permeability coefficient and enhancement ratio.

키워드

PGE₁ urethral suppositories stability enhancer