만병초의 세포독성 성분

• 영문명: Cytotoxic Constituents of Rhododendron brachycarpum
• 발행기관: 대한약학회
• 저자명: 장기욱(Gi Uk Jang) 최상운(Sang Un Choi) 이강노(Kang Ro Lee)
• 간행물 정보: 『약학회지』제49권 제3호 (2005년), 244~248쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2005.06.30

영문 초록

From the methanol extract of Rhododendron brachycarpum four triterpenes, three phenylpropanes and a diterpene alkaloid were isolated. Their structures were identified as glutinol (1), 3β-hydroxyurs-12-ene (2), β-sitosterol (3), (E)-p-hydroxycinnamic acid hexadecylester (4), (-)-rhododendrol (5), (+)-rhododendrol (6), 3β-hydroxyurs-12-en-28-oic acid (7) and gray-anotoxin I (8) by spectroscopic methods. Compound 8 showed moderate cytotoxicity against five cultured human tumor cell lines with ED50 values of 3.21~4.05 μg/ml. The other compounds were of marginal activity against the tested cell lines.

키워드

Rhododendron brachycarpum cytotoxicity