프로카인아미드의 HPLC 분석법 및 한국인에서의 약동학적 특징

• 영문명: HPLC Determination and Pharmacokinetic Profile of Procainamidein Korean Subjects
• 발행기관: 대한약학회
• 저자명: 배정우(Jung-woo Bae) 김현경(Hyun-Kyung Kim) 양상인(Sang-In Yang) 김지홍(Ji-Hong Kim) 김경혜(Kyung-Hye Kim) 장춘곤(Choon-Gon Jang) 박영서(Young-Seo Park) 손의동(Uy-Dong Sohn) 이석용(Seok-Yong Lee)
• 간행물 정보: 『약학회지』제49권 제3호 (2005년), 193~197쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2005.06.30

영문 초록

Procainamide is the drug of second choice (after lidocaine) in most coronary care units for the treatment of sustained ventricular arrhythmias associated with acute myocardial infarction. The purpose of this study was to develop the efficient assay method of procainamide in human plasma and to assess the pharmacokinetic profile of procainamide in healthy Korean volunteers. The pharmacokinetics of procainamide administered orally was evaluated after a dose of 250 mg. Procainamide in plasma was assayed using a specific HPLC method with UV absorbance at 275nm. AUC was 4.58±0.90 μg/ml.hr, Cmax 1.34±0.39 μg/ml, Tmax 1.06±0.34 hr and half-life 3.07±0.34 hr. Tmax was slightly shorter than that in Caucasian (1~2hr), whereas the half-life was similar to that in Caucasian (2.5~4.1 hr).

키워드

procainamide Pulcan capsules HPLC