알킬할라이드와 Triethylamine을 이용한 일급 아로미틱 아민의 N-알킬레이션

• 영문명: N-Alkylation of Primary Aromatic Amines Using Alkylhalide and Triethylamine
• 발행기관: 대한약학회
• 저자명: 김주희(Ju-Hee Kim) 박명숙(Myung-sook Park)
• 간행물 정보: 『약학회지』제49권 제2호 (2005년), 162~167쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2005.04.30

영문 초록

Synthetic method for the selective N-monoalkylation of anilines using alkyl halides and triethylamine under room temperature was described. The corresponding N-alkylanilines were obtained in good yields with minor quantities of dialkylated products. Anilines 2a-m and 3a-m were identified using NMR and IR. A series of 2a-m and 3a-m has been synthesized from aniline, toluidines, ethylanilines, aminoacetophenones, phenetidines. Formation of anilines was undertaken with dropping of alkylhalides at room temperature in methanol (or ethanol) for 3 hours~5 days. Selectivity on the monoalkylation was relatively high. Synthetic ratio of monoalkylated and dialkylated product was 94 : 6 in case of maximum monoalkylation.

키워드

N-alkylation amino-dehalogenation triethylamine N-mono(N,N-di)alkylanilines alkyl halides