와파린의 HPLC 분석법 및 한국인에서의 약동학적 특징

• 영문명: HPLC Determination and Pharmacokinetic Profile of Warfarin in Korean Subjects
• 발행기관: 대한약학회
• 저자명: 배정우(Jung-Woo Bae) 김현경(Hyun-Kylug Kim) 양상인(Sang-ln Yang) 김지홍(Ji-Hong Kim) 김경혜(Hrung-Hye Kim) 장춘곤(Choon-Gon Jang) 박영서(Young-Seo Park) 손의동(Uy-Dong Sohn) 이석용(Seok-Yong Lee)
• 간행물 정보: 『약학회지』제49권 제2호 (2005년), 134~139쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2005.04.30

영문 초록

Warfarin is a widely used oral anticoagulant agent used to treat thromboembolic disease. The purpose of this study was to develop the efficient assay method of warfarin sodium in human plasma and to assess the pharmacokinetic profile of the warfarin in healthy Korean volunteers. The pharmacokinetics of warfarin administered orally was evaluated after a dose of 10 mg. Warfarin in plasma was assayed using a specific HPLC method with UV absorbance at 304 nm. AUC was 46.33±9.95㎍/㎖.hr, Cmax 1.22±0.22㎍/㎖, Tmax 2.50±1.41 hr and half-life 43.49 ±4.33 hr. Tmax, was slightly shorter than that in Caucasian (3~9 hr), whereas the half-life was longer than that in Caucasian (10~45 hr, mean: 36 hr). These results suggest that warfarin may have a longer duration in Korean than in Caucasian.

키워드

warfarin sodium coumadin tablets HPLC