간효소에 의해 대사된 양격산화탕의 저산소/재관류로부터 PCl2 세포 보호효과

• 영문명: Protective Effect of Yangguksanwha-tang Metabolized by Liver Homogenate on Hypoxia-reperfusion Induced PCl2 Cell Damage
• 발행기관: 대한약학회
• 저자명: 소윤조(Yunjo Soh)
• 간행물 정보: 『약학회지』제49권 제1호 (2005년), 97~102쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2005.02.28

영문 초록

The protective effect of Yangguksanwha-tang (YST) against hypoxia-reperfusion insult was investigated in PC12 cells. To elucidate the mechanism of the protective effect of YST, cell viability the changes in activities of superoxide dismutase, glutathione peroxidase, catalase, caspase 3 and the production of malondialdehyde were observed after treating PC12 cells with YST which was metabolized by rat liver homogenate. Pretreatment of YST with liver homogenate appeared to increase its protective effect against hypoxia-reperfusion insult. The result showed that YST had the highest protective effect against hypoxia/reperfusion at the dose of 2㎍/ml in PC12 cells, probably by recovering the redox enzyme activities and MDA to control level.

키워드

Yangguksanwha-tang antioxidant activity hypoxia/reperfusion