인삼사포닌에 의한 대식세포 일산화질소 생성 유도

• 영문명: A Ginseng Saponin Induces Production of Nitric Oxide in Macrophages
• 발행기관: 대한약학회
• 저자명: 김지연(Ji Yeon Kim) 이화진(Hwa Jin Lee) 김지선(Ji Sun Kim) 안한나(Hanna Ahn) 류재하(Jae-Ha Ryu)
• 간행물 정보: 『약학회지』제49권 제1호 (2005년), 80~85쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2005.02.28

영문 초록

Ginseng root is an important remedy in oriental countries, which has been used for thousands of years. Saponins of ginseng root has been known to be the major component which mediate diverse pharmacological actions of the ginseng. Heat processing of ginseng root potentiates its biological activity such as anti-tumor and anti- oxidative activities. The butanol fraction of heat-processed ginseng (HGB) induced the production of nitric oxide in macrophages in a dose-dependent manner with IFN-γ (30 U/ml) priming. The active component was identified as ginsenoside-Rg5 from the activity-guided purification. Ginsenoside Rg5 is one of major components of heat-processed ginseng and red ginseng that is responsible for the potentiated biological activities of processed ginseng. The induction of NO production by heat-processed ginseng might contribute to the potentiated biological activity of heat-processed ginseng.

키워드

nitric oxide heat processing ginseng saponin