삼릉추출물이 항산화와 멜라노제네시스에 미치는 영향

• 영문명: Effects of the Sciripi rhizoma on Antioxidation and Melanogenesis
• 발행기관: 대한약학회
• 저자명: 이경은(Kyung Eun Le) 심관섭(Gwan Sub Sim) 김진화(Jin Hwa Kim) 박성민(Sung Min Park) 이범천(Bum Chun Lee) 윤여표(Yeo Pyo Yun) Yong He Zhang 표영배(Hyeong Bae Pyo)
• 간행물 정보: 『약학회지』제48권 제6호 (2004년), 323~327쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2004.12.31

영문 초록

Whitening effect, which decreases the skin pigmentation, is the one of important targets in cosmetics. This study was investigated the effects of Scirpi rhizoma on antioxidation and melanogenesis. S.rhizoma is a rhizome of Scirpus fluviatilis G. a perennial Cyperaceae species of wide occurrence in Asia, Europe, Africa and North America. S.rhizoma shown scavenging activities of free radicals and reactive oxygen species (ROS) with the IC50 of 638㎍/ ㎖ against 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and 21.7㎍/㎖ against superoxide radicals in the xanthine/xanthine oxidase system, respectively. S.rhizoma treatment (48 h) suppressed the biosynthesis of melanin up to 27% and reduced tyrosinase activity up to 31% at 100㎍/㎖ in B16 melanoma cells. S.rhizoma was also able to significantly inhibit tyrosinase and TRP-1 expres- sion in protein level. These results suggest that S.rhizoma inhibited melanin biosynthesis by regulating tyrosinase activity and expression in B16 melanoma cells. Therefore S.rhizoma may be useful as new whitening agent due to the antioxidant effect and the inhibitory effect against melanogenesis.

키워드

Scirpi rhizoma antioxidation melanogenesis tyrosinase