화상 및 창상 치료용 외용제제 개발에 대한 기초 연구

• 영문명: Studies on the Wound Healing by the PVA-soft hydrogel
• 발행기관: 대한약학회
• 저자명: 조동현(Dong-hyun Cho) 신영희(Young-hee Shin)
• 간행물 정보: 『약학회지』제48권 제1호 (2004년), 55~59쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2004.02.28

영문 초록

A PVA-soft hydrogel, which is a semi-solid form in container whereas after applying on the skin, it formed a thin layer within a few minutes. In this study, we prepared a novel type PVA-soft hydrogel containing 6-methyluracil as active drug, and the therapeutic value was characterized. To evaluate the therapeutic value of the PVA- soft hydrogel containing drug, various animal models, thermal burn model, incision & excision wound rat model were used. We also measured the wound size and breaking strength to calculate the wound healing extent after single or multiple administration. The wound size of soft hydrogel treated group decreased rapidly than that of control group after multiple dosing in excision wound model. And, the breaking strength of the soft hydrogel treated group was greater than that of control group in incision wound model.

키워드

soft-hydrogel wound healing thermal burn model incision & excision wound model.