Mancozeb의 급성노출이 마우스의 면역기능에 미치는 영향

• 영문명: Effects of Acute Oral Administration of Mancozeb on the Immune Function in Mice
• 발행기관: 대한약학회
• 저자명: 정애희(Ae-Hee Cheong) 표명윤(Myoung-Yun Pyo)
• 간행물 정보: 『약학회지』제48권 제1호 (2004년), 41~46쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2004.02.28

영문 초록

Mancozeb, a polymeric complex of zinc and manganese salts of ethylene bisthiocarbamate (EBDC), is used widely in agriculture as fungicides, insecticides, and herbicides. Mancozeb can be occupationally and environmentally exposed to human and has been reported to induce estrogenic activity, therein it is considered as an endocrine disrupter, We investigated the effects of acute exposure of Mancozeb on the immune function in mice. After single oral administration of Mancozeb to female ICR mice, the immunopathological parameters (body- and organ-weight, splenic cellularity, hematological parameters), mitogen (Con A, PHA+IL-2, LPS)-induced splenocyte proliferation (SP) and splenic IgM plaque forming cell (PFC). WBC and splenic cellularity were decreased, but liver-, kidney-, and spleen-weight were increased when compared with control group. Splenic IgM PFC against SRBC was slightly lowered. Mitogen-induced proliferation of spleen cells from Mancozeb-treated mice was not significantly changed ex vivo, however, SP in vitro were significantly lowered in concentration dependent manner. These results Indicate that Mancozeb could affect the immune function in mice.

키워드

Mancozeb immunopathology IgM PFC splenocyte proliferation.