니페디핀과 파크리탁셀의 약물동태학적 상호작용

• 영문명: Pharmacokinetic Interaction between Nifedipine and Paclitaxel in Rats
• 발행기관: 대한약학회
• 저자명: 최준식(Jun Shik Choi) 이종기(Chong Ki Lee)
• 간행물 정보: 『약학회지』제48권 제1호 (2004년), 1~5쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2004.02.28

영문 초록

The purpose of this study was to investigate the effect of coadministration and 3 days-pretreatmemt of nifedipine (2, 10 mg/kg) on the pharmacokinetic parameters and bioavailability of paclitaxel (50 mg/kg) after oral administration in rats. Coadministration of nifedipine with paclitaxel did alter the Cmax (l15±29 ng/ml without nifedipine; 135±35 ng/ml with nifedipine (10 mg/kg); p<0.05) and AUC (188±459 ng/ml·hr without nifedipine; 2546±642 ng/ml·hr with nifedipine; p<0.05). Three days treatment of nifedipine on the prior to paclitaxel administration increased the t1/2[9.90±2.47 hr without nifedipine; 12.37±3.12 hr with nifedipine (2 mg/kg); 12.83±3.32 hr with nifedipine (10 mg/ml); p<0.05] and AUC [1833 ±459 ng/ml·hr without nifedipine; 2663±648 ng/ml·hr with nifedipine (2 mg/kg); 3006±734 ng/ml·hr with nifedipine (10 mg/ml); p<0.05]. Drug interaction between nifedipine and paclitaxel decreased the elimination rate constant and increased the oral bioavailability of paclitaxel. On the basis of the results of this study, it might be considered that nifedipine may inhibit cytochrome P45O, which are engaged in paclitaxel metabolism, result in increased t1/2 and AUC of paclitaxel. Howeverl further study should be conducted to clarify the roles of cytochrome P45O and P-glycoprotein on paclitaxel bioavailability with/or without nifedipine.

키워드

paclitaxel pharmacokinetics nifedipine drug interaction coadministration pretreatment.