6-Exomethylenepenam 유도체의 베타락타마제 효소억제력과 베타락탐항생제 병용시 활성비교

• 영문명: β-Lactamase Inhibitory Activity and Comparative Activity of 6-Exomethylenepenam Derivatives Combined with β-Lactam Antibiotics
• 발행기관: 대한약학회
• 저자명: 임채욱(Chaeuk Im) 박희석(Hee Suk Park) 정미량(Mi Lyang Chung) 강주성(Joo Sung Kang) 임철부(Chul Bu Yim)
• 간행물 정보: 『약학회지』제47권 제6호 (2003년), 456~460쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2003.12.31

영문 초록

In vitro β-lactamase inhibitory activity of 6-exomethylenepenam compounds (1,2,3,4 and 5) was compared with clavulanic acid, sulbactam and tazobactam. The inhibitory activity of compound 3 was stronger than those of sulbactam and clavulanic acid against Type I and II enzymes and stronger than tazobactam against Type III, IV, TEM enzymes. The inhibitory activity of 5 was stronger than sulbactam and clavulanic acid against Type I and II enzymes and stronger than tazobactam against Type III and IV enzymes. The in vitro antimicrobial activity of 3,4 and 5 combined with ampicillin and cefoperazone was compared with the sulbactam against β-lactamase producing 27 strains. But, synergistic activity of 3 and 5 was inferior to tazobactam.

키워드

antimicrobial activity β-actamase inhibitors 6-exomethylenepenam.