B16 Melanoma 세포에서 Chitosan Oligosaccharide가 Melanin 생성에 미치는 영향

• 영문명: Effect of Chitosan Oligosaccharide on Melanin Production in B16 Melanoma Cells
• 발행기관: 대한약학회
• 저자명: 조남영(Nam Young Cho) 윤미연(Mi Yun Yoon) 김경원(Kyoung Won Kim) 박영미(Young Mi Park) 임혜원(Hye Won Lim) 이지윤(Ji Yun Lee) 이진희(Jin Hee Lee) 김연정(Youn Joung Kim) 김창종(Chang Jong Kim) 심상수(Sang Soo Sim)
• 간행물 정보: 『약학회지』제47권 제6호 (2003년), 404~409쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2003.12.31

영문 초록

To investigate the effect of chitosan oligosaccharide on melanin synthesis, we measured tyrosinase activity and melanin production in B16 melanoma cells. Chitosan oligosaccharide itself did not have any anti-oxidant activity in DPPH radical scavenging, and did not affect the proliferation of B16 melanoma cells. Chitosan oligosaccharide dose-dependently increased melanin production in the absence or presence of MSH. However, chitosan oligosaccharide did not have any influence on the tyrosinase activity and tyrosinase expression in B16 melanoma cells these results suggest that chitosan oligosaccharide-induced melanin production may be independent on tyrosinase activity in B16 melanoma cells. From the above results. Chitosan oligosaccharide dose-dependently appears to increase melanin production in B16 melanoma cells, suggesting that chitosan oligosaccharide may be used as a tanning agent.

키워드

chitosan oligosaccharide melanin tyrosinase.