2-Arylethenylchromones 유도체의 합성 및 항암활성 검색

• 영문명: 2-Arylethenylchromones Derivatives : Synthesis and Anticancer Activity
• 발행기관: 대한약학회
• 저자명: 문창상(Chang Sang Moon) 이경원(Kyung-Won Lee) 이지용(Jiyong Lee) 이재열(Jae Yeol Lee) 정봉영(Bong Young Chung) 이경태(Kyung-Tae Lee) 이용섭(Yong Sup Lee)
• 간행물 정보: 『약학회지』제47권 제6호 (2003년), 376~381쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2003.12.31

영문 초록

2-Arylchromones, also known as flavones, are among the most ubiquitous classes of natural products occurring in the plant kingdom. On the other hand, 2-styrylchromones are relatively scarce in nature and only a few compounds has been isolated from the blue-green algae species. Therefore, new 2-arylethenylchromone derivatives (4a~n, 5a~f) were synthesized by the aldol condensation of 2-methylchromone (3) with several aromatic aldehydes in order to evaluate their cytotoxicities using a MTT assay on three tumor cells. 2-Arylethenylchromene derivative 4a showed the significant cytotoxic activities on KB, HL-60 and P-388 cell lines with IC50 values of 25.2, 63.59 and 49.51 μM, respectively, indicating that 2-arylethenylchromone skeleton has a potential anti-tumor application.

키워드

styrylchromone arylethenylchromone flavonoid aldol condensation cytotoxicity KB cell.