상엽과 산사엽 추출물이 사염화 탄소로 유발된 흰쥐의 간 손상에 미치는 영향

• 영문명: Effects of Mori Folium and Crataegus pinnatifida Leave Extracts on CCl4-induced Hepatotoxicity in Rats
• 발행기관: 대한약학회
• 저자명: 김형진(Hyoung-Jin Kim) 김증권(Jung-Kwon Kim) 황완균(Wan-Kyun Whang) 함인혜(In-Hye Ham) 권석형(Suck-Hyung Kwon) 황보식(Sik Hwang-Bo) 김흥진(Hong-Jin Kim)
• 간행물 정보: 『약학회지』제47권 제4호 (2003년), 206~211쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2003.08.30

영문 초록

This study was performed to investigate the effect of Mori Folium and Crataegus pinnatifida leave extracts on liver damage induced by CCl4 in rats. 30% and 60% methanol extracts of Mori Folium and Crataegus pinnatifida leaves were administered orally at the dose of 10 mg/kg on every day for 6 days and liver damage was induced by intraperitoneal injection of CCl4 (0.4 ml/kg) on 6th day. 30% Methanol extracts of Mori Folium treated group showed significant protective effect on hepatotoxicity with the lowest Glutamic Oxaloacetic Transaminase (GOT) and Glutamic Pyruvic Transaminase (GPT). The low density lipoprotein (LDL) levels of 30% methanol extracts Mori Folium and Crataegus pinnatifida leave and 60% methanol extracts of Mori Folium treated groups were significantly lower than normal group, respectively. In articular, LDL level of 30% Mori Folium extracts treated group was significantly decreased compared to CCl4 treated group. These results support that Mori Folium and Crataegus pinnatifida leave extracts are hepatoprotective effects against hepatotoxicity induced by CCl4.

키워드

Mori Foliumy Crataegus pinnatifida GOT(glutamic oxaloacetic transaminase) GPT(glutamic pyruvic transaminase) LDL(low density lipoprotein).