1,5-Diphenylhydantoins의 가수분해에 의한 N-Aryl Phenylglycine O-Alkyl Esters의 합성

• 영문명: Synthesis of N-Aryl Phenylglycine O-Alkyl Esters Using Hydrolysis of 1,5-Diphenylhydantoins
• 발행기관: 대한약학회
• 저자명: 박해선(Hae Sun Park) 최희전(Hee Jeon Choi) 권순경(Soon Kyoung Kwon) 박명숙(Myung Sook Park)
• 간행물 정보: 『약학회지』제47권 제3호 (2003년), 130~134쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2003.06.30

영문 초록

For the development of new synthetic method for unnatural amino acid esters, N- aryl phenylglycine O-alkyl esters 4a~I were synthesized through base-catalyzed hydrolysis of 1,5-diphenylhydantoins 1a~b and O-alkylation in 16~87% yield. An efficient and practical route for final 4a~I was that the starting materials 1a~b were heated in dil-meth-anol for 30 minute using sodium hydroxide or potassium hydroxide and evaporated. In addition, reaction mixture were refluxed for 1 h in DMF. All synthetic process from hydantoin to N-aryl phenylglycine O-alkyl esters 4a~1 could be carried out in one-pot without isolation of intermediates.

키워드

N-Aryl phenylglycine O-alkyl esters hydantoin ring opening unnatural amino acids.