피부면역계 랑게르한스세포의 TNF-α생산에 대한 Pedunculagin의 효과

• 영문명: Effect of Pedunculagin in production of TNF-αof Langerhans Cells
• 발행기관: 대한약학회
• 저자명: 주성수(Seong Soo Joo) 오원식(Won Sik Oh) 박정환(Jeong Hwang Park) 이도익(Do Ik Lee)
• 간행물 정보: 『약학회지』제46권 제6호 (2002년), 477~481쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2002.12.31

영문 초록

Ellagitannins have been reported to enhance the immune system. In this study; the effects of pedunculagin on langerhans cells were examined. Pedunculagin, an ellagitannin from Alnus hirsuta var, microphyllais a novel Immunomodulator, Langerhans cell are known as the potent antigen presenting cell and elicit the Contact Hypersensitivity (CHS) response by presenting Ag to trafficking Ag- specific T cells within the skin. For determining the effects of pedunculagin on murine langerhans cell, the expression of TNF-Αmrna was examined by RT-PCR. As a result, the expression of TNF-u myNA was upregulated by pedunculagin. These results suggest that pedunculagin enhances TNF-u and could be used as an immunomodulator in skin immune system.

키워드

Ellagitannin pedunculagin immunomodulator.