6-엑오메칠렌 Sulbactarn유도체의 합성

• 영문명: Synthesis of 6-Exomethylene Sulbactam Derivatives
• 발행기관: 대한약학회
• 저자명: 임채욱(Chae Uk Im) 정홍식(Hong Sik Jeong) 임철부(Chul Bu Yim)
• 간행물 정보: 『약학회지』제46권 제6호 (2002년), 381~386쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2002.12.31

영문 초록

The synthesis of new 6-ex(nnethylene sulbactam derivatives with 5-methyl-1,3,4- thiadiazole was described. The 6,6-dibromopenam 5 was reacted with CH3MgBr and carbaldehyde 4 to afford the 6-bromo-6-(1-hydroxy-1-methyl)penicillanate 6, which was treated with acetic anhydride to give acetoxy compound 7. The deacetobromination of acetoxr compound 7 with zinc and acetic acid gave 6-exomethylen penams, Z-isomer 8 and E-isomer 9, which was oxidiged to sulfones 10 by m-CPBA. The p- methoxybenzyl compounds 6-10 were deprotected by AIC13 and neutralized with NaOH solution to give the sodium salts 11-15.

키워드

beta-Lactamase inhibitors synthesis