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• 영문명: Determination of Hydrogen Peroxide Concentration by Portable Near-Infrared (NIR) System
• 발행기관: 대한약학회
• 저자명: 임현량(Hun Rang Lim) 우영아(Young Ah Woo) 장수현(Soo Hyun Chang) 김경미(Kyeong Mi Kim) 김효진(Hyo Jin Kim)
• 간행물 정보: 『약학회지』제46권 제5호 (2002년), 324~330쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2002.10.31

영문 초록

This experiment was carried out to determine non-destructively the hydrogen peroxide concentration of 3% antiseptic hydrogen peroxide solutions by portable near-infrared (NIR) system. Hydrogen peroxide standards were prepared ranging from 0 to 25.6 w/w% and the NIR spectra of hydrogen peroxide standard solutions were collected by using a quartz cell in 1 mm pathlength. We found the variation of absorbance band due to OH vibration of hydrogen peroxide depending on the concentration around 1400 nm in the second derivatives spectra. Fartial least square regression (PLSR) and mufftilinear regression (MLR) were explored to develop a calibration model over the spectral range 1100-1720 nm. The model using PLSR was better than that using MLR. The calibration showed good results with a standard error of prediction (SEP) of 0.16%. In order to validate the developed calibration model, routine analyses were performed using commercial antiseptic hydrogen peroxide solutions. The hydrogen peroxide values from the NIR calibration model were compared with the values from a redox titration method. The NIR routine analyses results showed good correlation with those of the redox titration method. This study showed that the rapid and non- destructive determination of hydrogen peroxide in the antiseptic solution was successfully performed by portable NIR system without very harmful solvents.

키워드

Hydrogen peroxide Near-infrared spectroscopy Routine analysis.