이온교환체로서 금속 -디 -2-피리딜케톤옥침 -산성의약품 3원 착물을 이용한 산성의약품의 정량

• 영문명: Determination of Acidic Drug with ISES Using Ternary Complex of Metal-di-2-pyridyl Ketone Oxime-acidic Drug as ton-Exchanger
• 발행기관: 대한약학회
• 저자명: 안문규(Moon Kyu Ahn) 오원정(Won Jung Oh) 이언경(Eon Kyung Lee) 이순영(Soon Young Lee) 이재윤(Jae Yun Lee) 정문모(Moon Mo Jung) 허문희(Moon Hye Hur)
• 간행물 정보: 『약학회지』제46권 제5호 (2002년), 320~323쪽, 전체 4쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2002.10.31

영문 초록

A method for the determination of acidic drug, mefenamic acid and ibuprofen with ion- selective electrode(ISE) using Fe(ll)-di-2-pyridyl ketone oxime complex as a counter ion were developed. Benzyl-2-nitrophenyl ether(BNPE) plasticized membrane was more selective and sensitive than the other tested membranes. The acidic drug selective electrode exhibits a linear response for 10-2 M 510-5 M of acidic drugs, mefenamic acid and ibuprofen with a slope of -55.9 and -56.3 mV/dec. in borate buffer solution (pH 8.9). Potentiometric selectivity measurements revealed negligible interferences from aromatic and aliphatic carboxylic acid salts. The electrodes were found to be useful for the direct determination of mefenamic acid and ibuprofen in pharmaceutical preparations.

키워드

ISE mefenamic acid ibuprofen Fe(II)-di-2-pyridyl ketone oxime.