Benzothiazole고리가 있는 6-엑소메칠렌 펜남 유도체의 합성

• 영문명: Synthesis of 6-Exomethylene Penams with Benzothiazole Ring
• 발행기관: 대한약학회
• 저자명: 임채욱(Cha Euk Im) 박희석(Hee Suk Park) 김승재(Seung Jae Kim) 임철부(Chul Bu Yim)
• 간행물 정보: 『약학회지』제46권 제5호 (2002년), 307~312쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2002.10.31

영문 초록

The synthesis of new 6-exomethylene penams with benzothiazole ring was described. The 6,6-dibromopenam 5 was treated with CH 3MgBr and carbaldehyde 4 to afford the 6-bromo-6-(1-hydroxy-1-methyl)penicillanate 6, which was reacted with acetic anhydride to give acetoxy compound 7. The deacetobromination of acetoxy compound 7 with zinc and acetic acid gave 6-exomethylene penams,Z-isomer 8 and E-isomer 9, which was oxidized to suuones 10 by m-CPBA. The p-methoxybenzyl compounds 6~10 were deprotected by AlC13 and neutralized to give the sodium salts 11~15.

키워드

6 -Exomethylene penam beta-Lactamase Inhibitors.