루판 유도체의 합성 및 세포독성 -I

• 영문명: Lupane Derivatives-I: Synthesis and Cytotoxic Activity
• 발행기관: 대한약학회
• 저자명: 유영제(Young Jae You) 김용(Yong Kim) 안병준(Byung Zun Ahn)
• 간행물 정보: 『약학회지』제46권 제5호 (2002년), 295~300쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2002.10.31

영문 초록

To observe the structure-activity relationship of lupane derivatives both on cytotoxic and aftiangiogenic activity twelve lupane derivatives were prepared; their antiangiogenic and cytotoxic activities were evaluated. Among them, four compounds were more cytotoxic than betulinic acid. Carboxylic acid at C28 seemed to be essential for cytotoxic activity. But, a selective cytotoxicity toward SK-MEL-2 was not observed. As for antiangiogenic activity none of the compounds except lupeol showed antiangiogenic activity at 30 μg/mL.

키워드

Lupane lupeol betulin betulinic acid cytotoxicity antiangiogenesis.