과량의 아연에 노출된 생쥐의 사이토카인 생산에 미치는 인도메타신의 영향

• 영문명: Effects of Idomethacin on the Production of Cytokines in Mice Exposed to Excessive Zinc
• 발행기관: 대한약학회
• 저자명: 채병숙(Byeong Suk Chae) 신태용(Tae Yong Shin)
• 간행물 정보: 『약학회지』제46권 제4호 (2002년), 258~264쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2002.08.31

영문 초록

Zinc plays an important role in immunobiological responses, while excessive Binc attenuates immune aulctions in a dose-dependent manner Zinc excess has been reported to increase levels of plasma prostaglandin I s (PGE2), which is known to inhibit production of Th (helper T) 1-associated cytokines and to induce inf1ammatory responses. Thus, this study was investigated the effects of indomethacin, a potent inhibitor of PGE2 synthesis, on the proinf1ammatory cytosine and Iymphokine production in ICR mice exposed to excessive zinc. Indomethacin at doses of 5 mg/kg was administered I.p. 30 minutes before zinc chloride (Zn) 30 mg/kg orally daily for 10 days. Excessive Zn remarkedly increased tumor necrosis factor (TNF)-α and interleukin (IL)-1β Levels in both serum and splenic supernatants compared with those in ontrols, while indomethacin significantly reduced the excessive Zn-induced levels of IL-1β. In serum, excessive Zn significantly decreased the levels of IL-2 and interferon (IFN)-γ compared with those in controls, whereas indomethacin significantly enhanced the excessive Zn-decreased levels of IFN-γ but did not affect the Zn-decreased levels of serum IL-2. In splenic supernatants, All of excessive Zn, indomethacin, and combination of Zn and indomethacin significantly enhanced IL-2 levels compared with those in controls, but indomethacin didn't affect the Zn-induced production of IL-2. These data, therefore, suggest that indomethacin significantly attenuated the in vivo and ex vivo IL-lβ production increased by excessive zinc and remarkedly enhanced the in vivo excessive zinc-suppressed production of IFN- γbut not IL-2.

키워드

Excessive zinc indomethacin IL-lbeta TNF-a IL-2 IFN-y PGE2.