정맥주입한 알콜이 횐쥐의 췌장 외분비에 미치는 영향

• 영문명: Effects of Intravenous Infusion of Ethanol on Exocrine Pancreatic Secretion of Rats
• 발행기관: 대한약학회
• 저자명: 심상수(Sang Soo Sim) 김창종(Chang Jong Kim)
• 간행물 정보: 『약학회지』제46권 제3호 (2002년), 192~196쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2002.06.29

영문 초록

To investigate the effect of intravenous ethanol administration on pancreatic exocrine secretion, we measured volume and protein amount in pancreatic juice and assayed amylase activity and phospholipase A 2 activity in pancreatic fragments and serum. Acute pancreatitis Induced by obstruction of common bile-pancreatic duct (CBPD) and caerulein infusion (57g7g1hr) showed typical characteristics, such as hyperamylasemia and pancreatic edema and increase of phospholipase A 2 activity in pancreatic fragments and serum. Intravenous ethanol infusion (50 mgHg/hr) significantly stimulated pancreatic exocrine secretion, but such a stimulatory effect of ethanol disappeared at dose of 100 mg/kg/hr without typical symptoms of acute pancreatitis. In microscopic examination, there were no typical changes of edematous pancreatitis in ethanol administrated rats. These results suggest that acute ethanol administration has dual effect on exocrine pancreatic secretion: low dose of ethanol (50 mg/hg/hr) stimulates pancreatic exocrine secretion, whereas high dose of ethanol (100 mghg/hr) does not without typical changes of edematous pancreatitis.

키워드

Amylase phospholipase A2 pancreatic exocrine secretion ethanol pancreatitis.