4,5-치환 3-alkoxy-6-allylthiopyridazine 유도체 합성

• 영문명: Synthesis of 4,5-substituted 3-alkoxy-6-allylthiopyidazine Derivatives
• 발행기관: 대한약학회
• 저자명: 권순경(Soon Kyoung Kwon)
• 간행물 정보: 『약학회지』제46권 제3호 (2002년), 155~160쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2002.06.29

영문 초록

Through a modification of allicin structure a disagreeable odor and chemical instability of allicin can be improved. 3-Alkoxy-6-allylthiopyridazine derivatives exhibit a superior effect for prevention and treatment of hepatic disease s induced by carbon tetrachloride and aflatoxin B1 and leer prevention of human tissues from radiation. These compounds inhibit also efficiently SK-Hep-1 cell proliferation through induction of apoptosis. So another 4,5-mono- or di-substituted 3-alkyloxy-6- allylthlopyridazine derivatives were synthesized on purpose to and out SAR of allylthiopyridazine in hepatoprotective and hepatotherapeutic acitivitis and to develop more effective drug candidate.

키워드

Pyridazine alkoxyallylthiopyridazine aryloxyallylthiopyridazine hepatoprotective hepatotherapeutic SKHep-1 cell aflatoxin B 1 1,2-diazine.