Monovalent와 bivalent aminoantipyrine 유도체의 합성과 항염 진통활성

• 영문명: Synthesis and Antiinflammatory-analgesic Activity of Monovalent and Bivalent Aminoantipyines
• 발행기관: 대한약학회
• 저자명: 김승재(Seung Jae Kim) 권오혁(Oh Hyeok Kwon) 전상철(Sang Chul Jun) 박상민(Sang Min Park) 임채욱(Chae Uk Im) 임철부(Chul Bu Yim)
• 간행물 정보: 『약학회지』제46권 제3호 (2002년), 149~154쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2002.06.29

영문 초록

Six novel 4-aminoantipyrine derivatives as potential nonsteroidal antiinflammatory and analgesic compounds were prepared and their antiiflammatory-analgesic activity were compared with antipyrine. Succinyl chloride and Ac20 were reacted with glycine, respectively to give glycine compounds (3-4, 9-10), which were treated with hydroxysuccinimide and dicyclohexyl carbodiimide to yield active esters (5-6,11-12), and then reacted with 4-aminoantipyrine to prepare 4-aminoantipyrine derivatives (7-8, 13-14). 4-Aminoantipyrine reacted with succinyl chloride and Ac20, respectively to give succinyl leis aminoantipyrine (15) and acetyl aminoantipyrine (16). Compounds (7), (8) and (13) gave comparable antiinflammatory activity to antipyrine.

키워드

Antipyrine amide analgesic agents antiinflammatory agents.