난용성 의약품의 생체이용률 증진을 위한 무정형 초미립자의 조제 : UDCA와 SLS의 혼합분쇄 효과

• 영문명: Amorphous Ultrafine Particle Preparation for Improvement of Bioabailability of Insolube Drugs: Effect of Co-Grinding of UDCA with SLS
• 발행기관: 대한약학회
• 저자명: 정한영(Han Young Chung) 곽성신(Seong Shin Kwak) 김현일(Hyun Il Kim) 최우식(Woo Sik Choi)
• 간행물 정보: 『약학회지』제46권 제2호 (2002년), 102~107쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2002.04.30

영문 초록

The particle size of medicinal materials is an important physical property which affects the pharmaceutical behaviors such as dissolution, chemical stability; compressibility and bioavailability of solid dosage forms. The size reduction of raw pharmaceutical powder is needed to formulize insoluble drugs or slightly soluble drugs and to improve the pharmaceutical properties such as the solubility the pharmaceutical mixing and the dispersion. The objective of the present study is to evaluate the grinding characteristics of ursodeoxycholic acid(UDCA) as a model of insoluble drugs. The effects of the grinding time and the amount of additive on particle size distribution of ground UDCA were investigated. Grinding of insoluble drug, UDCA and a series of dry co-grinding experiments of UDCA with sodium lauryl sulfate(SLS) as an additive were carried out uslng a planetary ball mill. It was measured that the median diameter and the particle size distribution of ground products with grinding WCh and additive SLS by Mastersizer. As a result of co-grinding of UDCA and SLS, the particle size of co-grinding products was decreased more than single grinding one. Howeverl it was observed that co-grindins products were reaggregated to larger particles after 120 min.

키워드

Ursodeoxycholic acid(UDCA) sodium lauryl sulfate(SLS) planetary ball mill.