ryloxyallylthiopyridazine 유도체 합성

• 영문명: Synthe s is of Aryloxyallylthiopyridaz me Derivatives
• 발행기관: 대한약학회
• 저자명: 권순경(Soon Kyoung Kwon) 김미경(Mi Kyung Kim)
• 간행물 정보: 『약학회지』제46권 제2호 (2002년), 89~92쪽, 전체 4쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2002.04.30

영문 초록

Allylthio group of the sulfur compounds of garlic oil plays an important role for prevention and treatment of hepatic diseases induced by toxic substances or carbon tetrachloride. Thus allylthio group as pharmacologically active group was introduced into pyridazine heterocycle ring. Aryloxyallylthiopyridazine derivatives were synthesized and their hepato-protective activities were screened in rat. The activities of these compounds were weaker than alkoxyallylthiopyridazine derivatives, which exhibit a superior hepatoprotective effect.

키워드

Pyridazine alkoxyallylthiopyridazine aryloxyallylthiopyridazine hepatoprotective 1,2-diazine.