횐쥐의 심혈관 기능에 대한 carbofuran의 독성작용

• 영문명: Carbofuran Induces Cardiovascular Dysfunction in Rat
• 발행기관: 대한약학회
• 저자명: 정이숙(Yi Sook Jung) 이수환(Soo Hwan Lee) 백은주(Eun Joo Baik) 문창규(Chang Kiu Moon) 문창현(Chang Hyun Moon)
• 간행물 정보: 『약학회지』제45권 제6호 (2001년), 739~745쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2001.12.31

영문 초록

Of all pesticides, carbamates are known to be most common, stance alternatives such as orcanophosphates have long lifetime and are extremely toxic to produce a delayed neurotoxic effect. Although a number of studies about toxicity of carbofuran, a most widely used carbamate, have been reported, its cardiovascular toxicity has not yet been studied. In the present study; we investigated its cardiovascular toxic effect in anesthetized rat in vivo and in isolated Langendorff rat heart. In anesthetized rat model, carbofuran (10 mg/tg) signiscantly reduced heart rate, and transiently increased blood pressure. In isolated rat heart, carbofuran (10mcM) caused a significant depression in the left ventricular developed pressure (LVDP), indicating contractile dysfunction by carbofuran. Carbofuran (10mcM) also decreased coronary flow rate (CFR) in isolated heart, indicating carbofuran-induced coronary dysfunction. These results suggest that carbofuran can cause cardiac dysfunction in rat in vivo and vitro.

키워드

Carbofliran heart blood pressure.