느릅나무의 에틸 아세테이트 추출물에 의한 Melanin생성 효과

• 영문명: Effects of Ethyl Acetate Extract from Ulmus davodoama var. japonica on Melanogenesis
• 발행기관: 대한약학회
• 저자명: 천현자(Hyun Ja Chun) 정승일(Seung Il Jeong) 김일광(Il Kwang Kim)
• 간행물 정보: 『약학회지』제45권 제6호 (2001년), 724~729쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2001.12.31

영문 초록

Melanogenesis is a physiological process resulted in the synthesis of melanin pigments, which has a role in protecting skin from the damaging effect of ultra-violet (UV)radiation. The main aim of the present study was to examine the effect of Ulmus davidiana var. japonica (UL) on melanogenesis. Cells were cultured in the presence of various concentrations of Ulmus davidiana var. japonica For 48 h, and there were estimated total melanin contents as a final product and activity tyrosinase, a key enzyme, in melanogenesis. Among the four solvent extracts tested, EtOAc extract mostly increased tyrosinase activity And EtOAc extract increased the melanin contents and tyrosinase activity in a dose-dependent manner, Especially it was observed that 100mcg/ml/ EtOAc extract promotes melanin secretion in B16/F10 melanoma cells by 140% at 48 h treatment and activity of increased by 180% in the presence of same concentration. In conclusion, as for EtOAc extract treatment, there was no effect on the viability of B16/F10 cell, only to stimulate melanization.

키워드

Ulmus davidiana var. japonica (UL) melanogenesis tyrosinase activity melanin content.