인진쑥 물추출물의 조다당체에 의한 Melanin 생성억제 효과

• 영문명: Inhibitory Effects of Crude Polysaccharide of Water Extract ofArtemisia iwayomogi Kitamura on Melanin Biosynthesis
• 발행기관: 대한약학회
• 저자명: 천현자(Hyun Ja Chun) 안병용(Byung Yong Ahn) 한종현(Jong Hyun Han) 우원홍(Won Hong Woo)
• 간행물 정보: 『약학회지』제45권 제6호 (2001년), 701~707쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2001.12.31

영문 초록

Melanogenesis is a physiological process resulting in the synthesis of melanin pigment. We investigated the inhibitory effect of crude polysaccharide of water extract of polysaccharide of water extract of Artemisia iwayomogi Kitamura (AI) on melanin biosynthesis in B16/F10 melanoma cells. Crude polysaccharide of water extract of Artemisia iwayomogi Kitamura signifcantly inhibited tyrosinase activity and melanin contents with or without α-MSH in vitro. Melanin contents and tyrosinase activity were decreased in a dose-dependent manner. These results show that crude polysaccharide of water extract of Artemisia iwayomogi Kitamura Could be developed as skin whitening components of cosmetics.

키워드

Artemisia iwayomogi Kitamura(AI) melanin biosynthesis tyrosinase a-MSH retinoic acid(RA) arbutin.