Ethanol이 횐쥐의 복강비만세포에서 Histamine유리에 미치는 영향

• 영문명: Effect of Ethanol on Histamine Release from Rat Peritoneal Mast Cells
• 발행기관: 대한약학회
• 저자명: 김창종(Chang Jong Kim) 이윤혜(Yun Hye Lee) 이승준(Seung June Lee) 서무현(Moo Hyun Seo) 장용운(Yong Un Jang) 심상수(Sang Soo Sim)
• 간행물 정보: 『약학회지』제45권 제6호 (2001년), 677~682쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2001.12.31

영문 초록

To investigate action of ethanol on histamine release from rat peritoneal mast cells, we compared the inhibitory effect of ethanol with those of calcium antagonists in mechanism of between ATP and compound 48/80-induced histamine release. Ethanol dose- dependently inhibited 1007M ATP-induced histamine release, whereas did not inhibit 1 mcg/ml compound 4a/80-induced histamine release. Verapamil,TMB-8 and EGTA dose- dependently inhibited ATP-induced histamine release, but did not inhibit compound 48/80-induced histamine release. Such an inhibitory effect of calcium antagonist was similar to that of ethanol. These results suggest that the inhibitory effect of ethanol on histamine release from rat peritoneal mast cells is mediated via disturbance of calcium mobilization.

키워드

Mast cells histamine ethanol calcium antagonist.