황기 부탄을 분획물이 생쥐의 체액성 면역기능에 미치는 영향

• 영문명: Effects of the Butanol Fraction of Astragali Radix on the Humoral Immune Function in Mice
• 발행기관: 대한약학회
• 저자명: 김정훈(Joung Hoon Kim) 문연자(Yeun Ja Mun) 이성원(Sung Won Lee) 임숙정(Sook Jung Im) 박정숙(Joung Suk Park) 우원홍(Won Jung Im)
• 간행물 정보: 『약학회지』제45권 제6호 (2001년), 670~676쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2001.12.31

영문 초록

Effects of the butanol fraction of Astragali Radix (BFAR) on the humoral immune response were investigated in ICR mice. Mice were divided into 4 groups and BFAR at doses of 5,25 and 125 mg/kg were administered orally to mice daily for 3 weeks, and the normal animals were given vehicle. The results of this study are summarized as follows; the relative weight of spleen was markedly increased by BFAR treatment, compared with that in normal mice. However, the body weight gain and the relative weight of liver were not affected. Splenic plaque forming cells and hemagglutination titers to sheep red blood cells, and the secondary IgG antibody response to bovine serum albumin were also dose-dependently enhanced by BfAR treatment. In these mice, BfAR did not increase serum alanine aminotransferase, total protein, serum albumin and albumiuglobulin ratio when compared with those in normal mice. Thus, these findings indicate that BFAR significantly enhances humoral immune response to antigen in concentrations that do not affected liver function.

키워드

Astragali Radix humoral immune response liver function mice.