영지버섯 균사체 (Ganoderma lucidum IY009)로부터 추출한 단백다당체의 항암활성

• 영문명: Antitumor Activities of the Proteoglycans from the Mycelium of Ganoderma lucidum IY009
• 발행기관: 대한약학회
• 저자명: 백성진(Seong Jin Baek) 김용석(Yong Seok Kim) 용환미(Hwan Mee Yong) 채주병(Ju Byung Chae) 윤환민(Hwan Min Yun) 박동우(Dong Woo Park) 김동연(Dong Yeon Kim) 이정옥(Jeong Ok Lee) 이준우(June Woo Lee) 박승국(Seung Kook Park)
• 간행물 정보: 『약학회지』제45권 제6호 (2001년), 641~649쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2001.12.31

영문 초록

In this study, the antitumor activities were investigated using β-Immunan, a proteoglycan obtained from cultured mycelia of the IYO09 strain of Ganoderma lucidum IY009belonging to basidiomycetes. The result showed the significant effect of cytotoxicity test against murine sarcoma 180 and murine Iymphocytic leukemia L1210 using immunized macrophage cultures by β-Immunan. When intraperitoneally injected at 40 mg/kg/day daily for 10 days, β-Immunan inhibited the growth of sarcoma 180 solid tumor in ICR mice by 88.8% (p<0.05). It was also observed that β-Immunan increased life span by 85.2% (p<0.01) after treatment of 100 mg/kg/day in BDFI mice bearing Iymphocytic leukemia L1210. And combination therapy with cisplatin (dosage: 4 mg/kg) increased life span by 140.4% (p<0.05) after treatment of 100 kg/mg/day in BDFI mice bearing Iymphocytic leukemia L1210.

키워드

Ganoderma lucidum IY009 beta-Immunan sarcoma 180 proteoglycan antitumor activity life span.