Ibuprofen이 함유된 Microemulsion의 제조 및 떵가

• 영문명: Preparation and Characterization of Microemulsion containing Ibuprofen
• 발행기관: 대한약학회
• 저자명: 양재헌(Jae Heon Yang) 김영일(Young Il Kim) 김현주(Hyun Ju Kim) 정규호(Kyu Ho Chung)
• 간행물 정보: 『약학회지』제45권 제6호 (2001년), 634~640쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2001.12.31

영문 초록

Ibuprofen is one of the nonsteroidal anti-inflammatory drugs (NSAID) and has shown anti-inflammatory antipyretic, and analgesic activity in both animals and humans. But it causes gastric mucosal abnormalities including edema, erythema, and submucosal petechial hemorrhages and erosin in human. In addition, based on the pharmaceutical point of views the compression and dissolution ability of ibuprofen is known as poor Therefore we studied to develop novel formulation containing water-insoluble drug, ibu- profen, using microemulsion consisting of surfactant, oil phase, and water phase was prepared for the purpose of increasing its bioavilability The physicochemical properties such as particle sixte, dissolution rate, solubility of ibuprofen in the system were determined. After oral administration of ibuprofen containing the microemulsion system, to Sprague-Dawley rats, pharmacokinetic parameters were also obtained. For the formulation in the study; oleic acid, linoleic acid, and several kinds of glycerides and triglycerides were used as an oil phase with several surfactants. Diethylene glycol monoethyl ether (Transcutof？？ ) or saturated polyglycolized glycerides (Labrasol？？) as surfactant was used, the domain of microemulsion was wide. The diameter of o/w microemulsion was ranged from 90 to 220 nm. Microemulsion, prepared with unsaturated polyglycolized glycerides (Labrafil？？) and the 2 : 1 molar mixture of diethylene glycol monoethyl ether (Transcutol？？)/polyoxyethylene(4) lauryl ether (Brij？？ 30), is expected to be promising system that increased the bioavilability of ibuprofen.

키워드

Ibuprofen Microemulsion Surfactant Bioavailability.