(S)-5-요오드 -2-아미노인단·염산염의 합성

• 영문명: Synthesis of (S)-5-iodo-2-aminoindan HCI
• 발행기관: 대한약학회
• 저자명: 마은숙(Eun Sook Ma)
• 간행물 정보: 『약학회지』제45권 제6호 (2001년), 582~587쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2001.12.31

영문 초록

(S)-5-lodo-2-aminoindan HCI (7) was synthesized for developing a serotonergic agent. (S)-Phenylalanine was protected with trifluoroacetyl group and compound 2 was prepared by direct iodination in acetic acid and in the presence of I2, KIO4, and sulfuric acid. Compound 3 was cyclized by Friedel-Crafts reaction and reduced with NaBH4 to form 5-iodo-2-(N- trifluroacetyl) aminoindan-1-ol (4) . This compound was reduced to indan derivative 5 using the triethylsilane and BF3 · Et2O. It was basified with K2CO3 solution and treated with saturated HCI in ethyl ether to isolate compound 7.

키워드

(S)-5-Iodo-2-aminoindan ．HC1 serotonergic agent iodination.