Melibiose로부터 M-5 중간체 galactosylglycerol의 합성

• 영문명: Synthesis of Galactosylglycerol from Melibiose as M-5 Intermediate
• 발행기관: 대한약학회
• 저자명: 차배천(Bae Cheon Cha)
• 간행물 정보: 『약학회지』제45권 제6호 (2001년), 575~581쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2001.12.31

영문 초록

The galactolipid M-5, which showed anti-inflammatory activity is glycoglycerolipid isolated from the Okinawa marine sponge Phyllospongia foliascens. Glycolipids have been synthesized by various methods, especially it were generally known that synthetic method of M-5 analogue and synthetic method of various glycolipids by glycosidation after synthesis of glycerolipid part. The others, it was not suggested that synthetic method via glycosylglycerol obtained by degradation from diglycoside. This study was carried out to investigate the synthesis of galactosylglycerol melibiose as M-5 intermediate. Synthesis of galactosylglycerol was accomplished by selective protection of hydroxy group of sugar and diol cleavage by Pb(OAC)4. As a result, galactosylglycerol was synthesized by 8 steps pathway and their structures were elucidated by analysis instrument.

키워드

M-5 Antiimflammatory Glycolipid Galactosylglycerol Melibiose.