잠재성 항염효과가 있는 벤즈이소티아올린 유도체의 합성

• 영문명: Synthesis of Potential Antiinfammatory Benzisothiazoline Derivatives
• 발행기관: 대한약학회
• 저자명: 박명숙(Myung Sook Park) 윤명선(Myung Sun Yun) 김미경(Mi Kyung Kim) 권순경(Soon Kyung Kwon)
• 간행물 정보: 『약학회지』제45권 제6호 (2001년), 570~574쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2001.12.31

영문 초록

In order to discover new useful NSAIDS, novel N-substituted 1,2-benzisothiazoline-3- one 1,1-dioxide derivatives, which can exhibit potentially antiinflammatory activity were synthesized.1,2-Benzisothiazoline-3-one-N-acetic acids 6a, b were obtained from monochloroacetic acid and sodium 1,2-benzisothiazoline-3-ones in DMF by N- al1kylation reaction. N-Substituted 1,2-benzisothiazoline-3-one 1,1-dioxice derivatives 7a-e were synthesized through the coupling of compound 6a, b and several amines (aniline, 2-aminopyridine, 2- aminothiazole, 2-aminotetrazole) with dicyclohexylcarbodiimide in methylene chloride.

키워드

Noble 1,2-Benzisothiazolines NSAIDs.