Cinmetacin의 amide유도체 합성과 항염진통촬성

• 영문명: Synthes and Antiinflammatory-analgesic Activity of Cinmetacin Amides
• 발행기관: 대한약학회
• 저자명: 임채욱(Chaeuk Im) 홍용기(Yong Ki Hong) 임철부(Chul Bu Yim)
• 간행물 정보: 『약학회지』제45권 제6호 (2001년), 565~569쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2001.12.31

영문 초록

Five novel cinmetacin amide derivatives as potential nonsteroidal antiinflammatory and analgesic compounds were prepared and their antiinflammatory-analgesic activity was compared with cinmetacin. Cinmetacin and hydroxysuccinimide were reacted with dicyclohexyl carbodiimide to give cinmetacin active ester (4), which was treated with amines to yield cinmetacin amides (5-9). Compounds (5) and (9) gave stronger analgesic activity than cinmetacin and compounds (5), (6), (9) showed comparable antiin1ammatory activity to cinmetacin.

키워드

Cinmetacinamide Analgesic agents Antiinflammatory agents.