석이중 오르시놀 정량 및 급성독성

• 영문명: Quantative Analysis of Orcinol and Acute Toxicity of Gyrophora esculenta
• 발행기관: 대한약학회
• 저자명: 최혁재(Hyuck-Jai Choi) 김남재(Nam Jae Kim) 김동현(Dong-Hyun Kim)
• 간행물 정보: 『약학회지』제45권 제2호 (2001년), 169~179쪽, 전체 11쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2001.04.30

영문 초록

In previous study, Gyrophora esculenta showed siginificantly inhibitory effect on alpha-glucosidase in vitro and blood glucose elevation in vivo. In the isolating process of active substance, orcinol was separated from Gyrophora esculenta. Orcinol is kwown to be toxic, therefore, in this study, it was analyzed by the TLC densitometry method for quantitative determination from Gyrophora esculenta. The average amount of orcinol of Gyrophora esculenta was 0.2%. For the purpose of removing orcinol, the water extract of Gyrophora esculenta was sequentially fractionated by organic solvents, and the acute toxicity of each fraction was assedded in mice. Among them, the LD50 of butanol fraction was 1.19g/kg(p.o.) and the weight increase of mice in that group was somewhat retareded.

키워드

Gyrophora esculenta orcinol TLC densitometry acute toxicity