한국 성인환자의 임상약동학 자료를 이용한 반코마이신의 용량설정표(nomogram)의 개발

• 영문명: Development of vancomycin dosing nomogram based on clinical pharmacokinetic data of Korean adult patients
• 발행기관: 대한약학회
• 저자명: 배성미(SM Bae) 김상일(SI Kim) 강문원(MW Kang) 조혜경(HK Cho)
• 간행물 정보: 『약학회지』제45권 제2호 (2001년), 153~160쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2001.04.30

영문 초록

This research developed an intravenous(IV) vancomycin dosing nomogram based on the clinical pharmacokinetic data of Korean adult patients. Total 99 pairs of steady-state peak and trough serum concentrations of vancomycin were determined to assesss the approciateness of initial vancomycin dosing. Only 47.2% of the cases were within therapeutic range. To characterize the clinical pharmacokinetics(PK) of vancomycin, PK parameters including elimination rate constant(Ke), half-life(T1/2), clearance(Clvan), volume of distribution(Vd) were calculated by using one-compartment, first order pharmacokinetic equations. PK parameters were evaluated based on the differences of patients' renal function and age. Regression analysis showed a significant correlation between Clvan and Ccr(Clvan=-1.89+0.914Ccr, r=0.763) and between Ke and Ccr(Ke=-0.0037+0.00139Ccr, r=0.724). The realtionship between Ke and Ccr and the mean Vd were utilized for developing the nomogram to individualize the initial dosing regimen of vancomycin for the patients with various degrees of renal functions. The nomograms may be used as an efficient tool to determine safe and effective doses of vancomycin for the Korean adult patients.

키워드

Vancomycin nomogram clinical pharmacokinetics