2-(1-아미노아세칠옥시알킬)-1,4-디하이드로시-9,10-안트라퀴논유도체의 합성 및 세포독성 평가

• 영문명: 2-(1-Aminoacetyloxyalkyl)-1,4,-dihydroxy-9,10-anthraquoinone derivatives:synthesis and cytotoxic activitiy
• 발행기관: 대한약학회
• 저자명: 신동진(Dong-Jin Shin) 유영제(Young-Jae You) 안병준(Byung-Zun Ahn)
• 간행물 정보: 『약학회지』제45권 제2호 (2001년), 133~139쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2001.04.30

영문 초록

To improve water solubility of 1,4-dihydroxy-9,10-anthraquinone moiety, 23 of 2-(1-aminoacetylalkyl)-1,4-dihydroxy-9,10-anthraquinone derivatives, which contain nitrogen atom, were synthesized. Of the synthesized compounds, 18 compounds were more cytotoxic on L1210 cells than 2-(1-acetyloxyalkyl)-1,4-dihydroxy-9,10-anthraquinone as comparative structure. This results might be due to the increased hydrophilicity of the compounds.

키워드

1,4-Dihydroxy-9,10-anthraquinone cytotoxicity hydrophilicity