Coumarin 계물질 및 그 전구체의 담즙분비촉진 효과에 관한 연구

• 영문명: Choleretic activities of coumarins and their biological precursors
• 발행기관: 대한약학회
• 저자명: 한덕룡(Dug Ryong Hahn)
• 간행물 정보: 『약학회지』제13권 제2&3호 (1969년), 67~70쪽, 전체 4쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1969.09.30

영문 초록

Gall duct cannulated rats were given daphnetin, umbelliferone,4-hydroxycoumarin, dicoumarol, 4, 7-dihydroxycoumarin, 4, 7-dimethyl-5-hydroxycoumarin, coumarin-3-carboxylic acid, cinnamic acid, ferulic acid, caffeic acid by duodenal catheter at room temperature and output of bile flow was detected. All of the subjected compounds in this experiment indicated a significant effect on the biliary elimination except cinnamic acid alone. It is suggested that a relationship exists between chemical pattern and biological aid biological activity for coumarin derivatives and their precursors, and that the choleretic activity of these compounds requires hydroxylated cinnamic acid structure as the most fundamental chemical pattern.